Table 2.
The comparison of sensitivity and specificity of serological techniques for SFG infection
| Year | Location | Method | Sample type | Samples | % Sens | % Spec | Rickettsial species | Reference |
|---|---|---|---|---|---|---|---|---|
| 1975 | USA | IFA | Serum | 571 | 85–97 | 99–100 | RMSF | [69] |
| 1975 | USA | IFA | Serum | 42 | 86 | NA | SFG | [70] |
| 1983 | USA | IFA-IgG/M | Serum | 50 | 83–100 | 100 | RMSF | [71] |
| 1981–1984 | Georgia | IFA | Serum | 1774 | 94 | NA | RMSF | [65] |
| 1983 | USA | ELISA-IgG ELISA-IgM |
Serum | 50 | 93–100 100 |
100 100 |
RMSF | [71] |
| 2009 | India | ELISA-IgM | Blood | 161 | 91 | 100 | SFG & STG | [72] |
| 2010–2012 | India | ELISA-IgG/M | Serum | 103 | 85 | 100 | SFG | [73] |
| 1975 | USA | CF | Serum | 571 | 85.4 | 100 | RMSF | [69] |
| 1975 | USA | CF | Serum | 42 | 62 | NA | SFG | [70] |
| 1981–1984 | Georgia | CF | Serum | 1774 | 63 | NA | RMSF | [65] |
| 1975 | USA | WF | Serum | 42 | 21 | NA | SFG | [70] |
| 1981–1984 | Georgia | WF (OX-19) WF (OX-2) |
Serum | 1774 | 70 47 |
NA NA |
RMSF | [65] |
| 2001 | Sri Lanka | WF | Serum | 30 | 33 | 46 | SFG, STG & TG | [66] |
| 2009 | Central India | WF | Serum | 157 | 49 | 96 | SFG & STG | [72] |
| 1975 | USA | MA | Serum | 571 | 56.1 | 99 | RMSF | [69] |
NA, not available; ST, scrub typhus; MT, murine typhus; Sens, sensitivity; Spec, specificity; WF, Weil–Felix; CF, complement fixation; IFA, immunofluorescence assay; RMSF, Rocky Mountain spotted fever; SFG, spotted fever group Rickettsia; STG, scrub typhus group; TG, typhus group.