Table 2.
Age- and sex-adjusted associations between succinate levels and metabolic and body composition markers
| 12,13-diHOME | Succinate | |||
|---|---|---|---|---|
| β (95% CI) | p value | β (95% CI) | p value | |
| z-Weight | −0.05 (−0.11, 0.01) | 0.09 | −0.10 (−0.21, 0.01) | 0.07 |
| z-BMI | −0.00 (−0.15, 0.02) | 0.009 | −0.12 (−0.24, 0.004) | 0.06 |
| z-Systolic BP | −0.04 (−0.10, 0.03) | 0.27 | 0.08 (−0.03, 0.20) | 0.15 |
| z-Diastolic BP | −0.08 (−0.14, −0.01) | 0.018 | 0.05 (−0.07, 0.17) | 0.41 |
| Biochemistry | ||||
| z-Glucose | −0.12 (−0.19, −0.06) | 0.0002 | −0.10 (−0.22, 0.02) | 0.09 |
| z-Insulin | −0.09 (−0.16, −0.02) | 0.008 | −0.07 (−0.19, 0.06) | 0.28 |
| z-HOMA-IR | −0.10 (−0.17, −0.03) | 0.003 | −0.08 (−0.20, 0.04) | 0.19 |
| z-Triacylglycerol | −0.10 (−0.17, −0.04) | 0.002 | −0.06 (−0.18, 0.06) | 0.30 |
| z-Total cholesterol | −0.06 (−0.12, 0.01) | 0.07 | 0.04 (−0.08, 0.16) | 0.50 |
| z-HDL-cholesterol | 0.14 (0.08, 0.20) | 1.4 × 10−5 | 0.13 (0.02, 0.25) | 0.023 |
| z-NEFA | 0.15 (0.08, 0.21) | 1.1 × 10−5 | 0.19 (0.07, 0.31) | 0.002 |
| z-Glycerol | 0.15 (0.09, 0.21) | 1.1 × 10−6 | 0.29 (0.17, 0.41) | 1.2 × 10−6 |
| z-β-OH butyrate | 0.12 (0.06, 0.19) | 1.5 × 10−4 | 0.12 (−0.01, 0.24) | 0.07 |
| z-Lactate | −0.05 (−0.12, 0.01) | 0.10 | 0.21 (0.08, 0.33) | 0.001 |
| DXA body composition | ||||
| z-Total fat mass | −0.08 (−0.15, −0.01) | 0.021 | −0.15 (−0.27, −0.03) | 0.015 |
| z-Total fat percentage | −0.11 (−0.16, −0.04) | 0.001 | −0.17 (−0.27, −0.06) | 0.002 |
| z-Visceral fat | −0.09 (−0.15, −0.03) | 0.004 | −0.11 (−0.22, −0.004) | 0.041 |
| z-Total lean mass | 0.001 (−0.04, 0.04) | 0.95 | −0.002 (−0.08, 0.08) | 0.97 |
Linear regression model adjusted for age and sex, with z-transformed values
β-values represent an SD change in 12,13-diHOME/succinate with corresponding SD change in metabolic and body composition traits