Table 2.
Diagnostic performance of the CAD-score and the updated Diamond-Forrester score (significant-CAD vs. other)
| All | AdoptCAD | Dan-NICAD | BIO-CAC | |
|---|---|---|---|---|
| CAD-score | ||||
| N: Other (Non-CAD and Mild-CAD) | 2033 | 141 | 1321 | 571 |
| N: Significant-CAD | 212 | 58 | 153 | 1 |
| Prevalence of CAD | 9.4% | 29.1% | 10.4% | 0.2% |
| True negative | 844 | 44 | 565 | 235 |
| False negative | 24 | 1 | 23 | 0 |
| False positive | 1189 | 97 | 756 | 336 |
| True positive | 188 | 57 | 130 | 1 |
| AUC | 0.750 (0.710–0.789) | 0.768 (0.690–0.846) | 0.720 (0.673–0.768) | – |
| Negative predictive value (p = 0.008) | 97.2% (95.9–98.2%) | 97.8% (88.2–99.9%) | 96.1% (94.2–97.5%) | – |
| Positive predictive value (p < 0.001) | 13.7% (11.9–15.6%) | 37% (29.4–45.2%) | 14.7% (12.4–17.2%) | – |
| Sensitivity (p = 0.02) | 88.7% (83.6–92.6%) | 98.3% (90.8–100%) | 85% (78.3–90.2%) | – |
| Specificity (p = 0.03) | 41.5% (39.4–43.7%) | 31.2% (23.7–39.5%) | 42.8% (40.1–45.5%) | 41.2% (37.1–45.3%) |
| Likelihood ratio positive | 1.52 | 1.43 | 1.49 | – |
| Likelihood ratio negative | 0.27 | 0.06 | 0.35 | – |
| Updated Diamond-Forrester score | ||||
| N: Other (Non-CAD and Mild-CAD) | 2033 | 141 | 1321 | 571 |
| N: Significant-CAD | 212 | 58 | 153 | 1 |
| Prevalence of CAD | 9.4% | 29.1% | 10.4% | 0.2% |
| True negative | 363 | 14 | 206 | 143 |
| False negative | 7 | 0 | 7 | 0 |
| False positive | 1670 | 127 | 1115 | 428 |
| True positive | 205 | 58 | 146 | 1 |
| AUC | 0.741 (0.702–0.781) | 0.661 (0.612–0.71) | – | |
| Negative predictive value (p = 0.072) | 98.1% (96.1–99.2%) | 100% (76.8–100%) | 96.7% (93.3–98.7%) | – |
| Positive predictive value (p < 0.001) | 10.9% (9.56–12.4%) | 31.4% (24.7–38.6%) | 11.6% (9.86–13.5%) | – |
| Sensitivity (p = 0.25) | 96.7% (93.3–98.7%) | 100% (93.8–100%) | 95.4% (90.8–98.1%) | – |
| Specificity (p < 0.001) | 17.9% (16.2–19.6%) | 9.93% (5.54–16.1%) | 15.6% (13.7–17.7%) | 25% (21.5–28.8%) |
| Likelihood ratio positive | 1.18 | 1.11 | 1.13 | – |
| Likelihood ratio negative | 0.18 | 0 | 0.29 | – |
Negative predictive values, specificity, True Negative, False Negative and Likelihood ratio negative are calculated for CAD-scores ≤ 20 and updated Diamond-Forrester scores < 15%. Positive predictive values, sensitivity, True Positive, False Positive and Likelihood ratio positive are calculated for CAD-scores > 20 and updated Diamond-Forrester scores ≥ 15%