Table 3.
Diagnostic performance of the CAD-scores in sub-groups
| n | Prevalence | AUC | Sensitivity | Specificity | NPV | PPV | |
|---|---|---|---|---|---|---|---|
| Gender | p < 0.0001 | p = 0.36 | p < 0.0001 | p < 0.0001 | p = 0.69 | p < 0.0001 | |
| Males | 1060 | 13.9% | 0.720 (0.671–0.769) | 94.6% (89.6–97.6%) | 27.3% (24.4–30.3%) | 96.9% (94.0–98.6%) | 17.3% (14.8–20.1%) |
| Females | 1185 | 5.5% | 0.688 (0.615–0.761) | 75.4% (63.1–85.2%) | 53.1% (50.2–56.1%) | 97.4% (95.8–98.5%) | 8.54% (6.4–11.1%) |
| Diabetes | p = 0.0001 | p = 0.15 | p = 0.26 | p < 0.0001 | p = 0.61 | p = 0.0061 | |
| Yes | 118 | 19.5% | 0.666 (0.535–0.797) | 95.7% (78.1–99.9%) | 22.1% (14.2–31.8%) | 95.5% (77.2–99.9%) | 22.9% (15.0–32.6%) |
| No | 2127 | 8.9% | 0.753 (0.712–0.794) | 87.8% (82.3–92.1%) | 42.5% (40.3–44.7%) | 97.3% (95.9–98.3%) | 13% (11.2–14.9%) |
| Symptoms | p < 0.0001 | p = 0.0066 | p = 0.012 | p = 0.66 | p = 0.076 | p < 0.0001 | |
| Typical chest pain | 490 | 19.6% | 0.795 (0.739–0.851) | 92.7% (85.6–97.0%) | 43.7% (38.7–48.7%) | 96.1% (92.1–98.4%) | 28.6% (23.7–34.0%) |
| Atypical chest pain | 608 | 9.9% | 0.691 (0.614–0.768) | 78.3% (65.8–87.9%) | 41.2% (37.1–45.5%) | 94.6% (90.9–97.1%) | 12.7% (9.5–16.6%) |
| Non-specific symptoms | 649 | 8.5% | 0.746 (0.669–0.823) | 92.7% (82.4–98.0%) | 40.9% (36.9–45.0%) | 98.4% (95.9–99.6%) | 12.7% (9.6–16.3%) |
| BMI | p = 0.53 | p = 0.013 | p = 0.73 | p < 0.0001 | p = 0.66 | p = 0.027 | |
| < 20 | 70 | 10.0% | 0.823 (0.628–1.00) | 100% (59.0–100%) | 58.7% (45.6–71.0%) | 100% (90.5–100%) | 21.2% (9.0–38.9%) |
| 20 and < 25 | 724 | 10.6% | 0.791 (0.729–0.852) | 89.6% (80.6–95.4%) | 49.5% (45.5–53.4%) | 97.6% (95.3–98.9%) | 17.4% (13.8–21.5%) |
| 25 and < 30 | 962 | 8.5% | 0.706 (0.641–0.771) | 86.6% (77.3–93.1%) | 39.7% (36.4–43.0%) | 96.9% (94.6–98.5%) | 11.8% (9.3–14.6%) |
| 30 | 483 | 9.3% | 0.750 (0.666–0.835) | 88.9% (75.9–96.3%) | 31.5% (27.2–36.1%) | 96.5% (92.0–98.9%) | 11.8% (8.5–15.7%) |
| Heart valve disease* | p = 0.81 | p = 0.53 | p = 0.37 | p = 0.006 | p = 0.56 | p = 0.90 | |
| Yes | 58 | 10.3% | 0.686 (0.440–0.930) | 100% (54.1–100%) | 23.1% (12.5–36.8%) | 100% (73.5–100%) | 13.0% (4.9–26.3%) |
| No | 2187 | 9.4% | 0.750 (0.710–0.790) | 88.3% (83.2–92.4%) | 42.0% (39.8–44.2%) | 97.2% (95.9–98.2%) | 13.7% (11.9–15.6%) |
Negative predictive values (NPV) and specificity are calculated for CAD-scores ≤ 20. Positive predictive values (PPV) and sensitivity are calculated for CAD-scores > 20
*Only the Dan-NICAD included subjects with heart valve disease