Table 2.
Results of multiple logistic regression analyses for assessing the relationships of stratified coffee intake with Aβ positivity in non-demented individuals
| Coffee intake | Aβ positivity | |
|---|---|---|
| OR (95% CI) | p Value | |
| Model 1 a | ||
| Lifetime | ||
| <2 cup/day | Reference | |
| ≥2 cup/day | 0.401 (0.208 to 0.772) | 0.006* |
| Current | ||
| <2 cup/day | Reference | |
| ≥2 cup/day | 0.453 (0.236 to 0.869) | 0.017 |
| Model 2 b | ||
| Lifetime | ||
| <2 cup/day | Reference | |
| ≥2 cup/day | 0.386 (0.197 to 0.757) | 0.006* |
| Current | ||
| <2 cup/day | Reference | |
| ≥2 cup/day | 0.443 (0.227 to 0.862) | 0.017 |
| Model 3 c | ||
| Lifetime | ||
| <2 cup/day | Reference | |
| ≥2 cup/day | 0.334 (0.162 to 0.689) | 0.003* |
| Current | ||
| <2 cup/day | Reference | |
| ≥2 cup/day | 0.402 (0.197 to 0.822) | 0.013 |
Aβ beta-amyloid, OR odds ratio, CI confidence interval, APOE4 apolipoprotein ε4, LCA lifetime cognitive activity, VRS vascular risk score, GDS geriatric depression scale
a Adjusted for age, gender, education, apolipoprotein ε4, and clinical diagnosis
b Adjusted for covariates in Model 1 plus, LCA score, occupational complexity, and annual income status, VRS, GDS score, smoking status, and alcohol status
c Adjusted for covariates in Model 2 plus, duration of coffee intake and age of first coffee intake
*Statistically significant (p < 0.00625)