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. 2019 Oct 22;9:15017. doi: 10.1038/s41598-019-51459-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Concordance of genomic alterations in tissue and cell-free DNA (cfDNA) among 6 samples. Twelve out of 16 variants in tumor DNA were detected in cfDNA. Of 26 variants in cfDNA, 14 were detected in cfDNA, but one TP53 variant was validated by the targeted amplicon sequencing of the tumor. Thirteen variants detected in cfDNA only and their variant allele frequency are shown. Driver gene variants such as AIRD1A.S1976F, NEE2L2.E79G and PIK3CA.P449A were also observed. ATM.C430G was detected in matched lymphocyte DNA by digital PCR.