Fig. 7.
Modeling of oncolytic virus therapeutic system. a Schematic diagram of the model with uninfected (S) and infected (I) cancer cells, free viruses (V), cytotoxic lymphocytes recognizing virus-specific antigen (ZV) and cancer-specific antigen (ZT), and immune effectors (F). Parameters are explained in “Methods”. b Predicted therapeutic efficacy of different administration strategies of replicable virus and immune effector, where immune effector was administrated along with or after the virus injection, or encoded by the virus. The initial amount of virus (MOI = 5 (one virus symbol) or 50 (three virus symbols)) and initial amount or production rate of immune effectors (10 a.u. (one star symbol) or 50 a.u. (three star symbols)) are noted on the bottom. Calculation of half killing time, maximum tumor size before half killing, response score and regression score is explained in “Methods”. Each matrix shows parameter combinations of cV (101.6 ~ 103.5 a.u.) and cT (101.2 ~ 103.1 a.u.)