. 2019 Oct 22;10:4648. doi: 10.1038/s41467-019-12652-1

Table 2.

Association of non-BC family history with interval breast cancer

Other cancer status^a	Family history in IC patients (%) (N)^b	Family history in SDC patients (%) (N)^b	OR (95% CI)^c
All patients	14.10 (454)	15.53 (2280)	0.935 (0.691, 1.249)
Any non-BC tumor	24.05 (79)	16.26 (289)	1.935 (1.001, 3.675)*
Any prior non-BC tumor	37.93 (29)	16.04 (106)	3.411 (1.284, 9.140)**
Any non-BC tumor after BC	17.31 (52)	15.71 (191)	1.484 (0.589, 3.523)

^a Stratification of patients according to non-BC tumor status

^b Family history of tumors other than breast cancer was only available in WHI and KARMA

^c Odds ratio and 95% confidence intervals (in brackets) of the assocation of non-BC tumor family history with interval breast cancer compared with screen-detected cancer in Caucasians. The logistic regression models were adjusted for age at diagnosis, study and the all non-BC cancer GRS

IC interval breast cancer, SDC screen-detected breast cancer, *P < 0.05; **P < 0.01, N number of individuals with non-missing family history information