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. 2019 Oct 22;10:4804. doi: 10.1038/s41467-019-12544-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Rasal1 inhibits in vivo T-cell activation by peptide antigen. a Upper: schematic of DO11.10 T-cell injection followed by OVA peptide injection and an assessment of LNs at day 5. b FACS profile of Rasal1 expression in T cells transfected with scrambled siRNA (left) and Rasal1 siRNA (right). c Rasal1 siRNA KD increases the size of lymph nodes, right inset: examples of LNs (scale bar, 2.5 mm). d Rasal1 KD increases the percent of DO11.10 T cells in lymph nodes; e Rasal1 KD increases the presence of DO11.10 T cell with the expression of proliferation marker Ki67; f Mean fluorescence intensity levels (MFIs) of various receptors. T cells were analyzed by flow cytometry for the expression of CD25, CD62L, and CD69 (n > 2)