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. 2019 Oct 22;10:4804. doi: 10.1038/s41467-019-12544-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Rasal1 KD T cells show reduced EL-4 tumor size concurrent with an increase in the presence of activated CD8 + TILs. a Upper panel: schematic of EL4 solid tumor experiment. Lower panel: quantification of tumor size in mice receiving OT-1 cells expressing control scrambled siRNA or Rasal1 KD siRNA T cells (n = 4 per group, lower panel). Upper inset panel shows representative images of some EL4 tumors from each group (scale bar, 5 mm). b Histogram showing an increase in the percentage of CD8+ TILs in mice injected with CD8 + Rasal1 KD relative to scrambled siRNA T cells (left panel). No increase was seen in the spleens of these mice (right panel). c Histograms showing an increase in the expression of CD25 and CD69 on CD8 + TILs from mice injected with control scrambled siRNA or with Rasal1 KD siRNA T cells. d Histograms showing the MFI values for CD44 expression (left panel) and the percentage of CD62L-positive CD8 TILs (right panel) from mice injected with scrambled siRNA or Rasal1 KD siRNA T cells