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. 2019 Oct 22;9:15111. doi: 10.1038/s41598-019-51159-z

Table 1.

Recurrence rates (RR) in different surgical approaches deriving from including all available studies from all geographical regions for 12, 24, 60, and 120 months follow-up time.

Surgical method (total patients included) 12 months 24 months 60 months 120 months Citations
RR in % (95% CI) Nr. at risk RR in % (95% CI) Nr. at risk RR in % (95% CI) Nr. at risk RR in % (95% CI) Nr. at risk
Primary open (6351) 1.3 (1.0–1.7) 5715 4.2 (3.6–4.8) 3496 13.9 (12.2–15.6) 1222 28.1* (23.9–32.4) 241* 20122
Primary median closure (15011) 3.1 (2.8–3.5) 12,484 8 (7.4–8.6) 6956 14.9 (13.8–15.9) 2505 27.9 (25.5–30.4) 631 20, 24, 27, 29, 31, 3438, 44, 46, 48, 52, 54, 56, 57, 59, 6166, 69, 7378, 8184, 86, 8991, 93100, 106108, 115, 118, 122248
Primary asymmetric closure (2538) 0.6 (0.3–0.9) 2432 1.1 (0.7–1.6) 1807 2.7 (1.9–3.6) 1205 6.3* (4.8–7.7) 937* 65, 67, 100, 129, 183, 192, 249263
Karydakis/Bascom (6276) 0.5 (0.3–0.7) 5868 1.6 (1.2–2.0) 3630 6.3 (5.0–7.5) 853 NA NA 16, 21, 29, 41, 49, 66, 78, 88, 133, 163, 172, 184, 189, 192, 195, 199, 200, 202, 262316
Limberg/Dufourmentel (11470) 0.3 (0.2–0.4) 10,937 1.5 (1.2–1.7) 7527 5.9* (5.1–6.7) 1638* NA NA 25, 28, 31, 33, 52, 56, 67, 92, 100, 127, 128, 130, 131, 137, 139, 140, 148, 149, 163, 165, 170, 172, 174, 182, 190192, 201, 205, 207, 208, 231233, 243, 246, 267, 268, 270, 272274, 291, 292, 295, 297, 305309, 311313, 317398
Marsupialization (1896) 2.2 (1.4–2.9) 1253 5.7 (4.2–7.1) 800 7.8* (5.9–9.6) 566* NA NA 30, 37, 46, 60, 65, 69, 71, 77, 78, 89, 97, 104, 110, 137, 152, 156, 175, 207, 208, 332, 399416
Limited excision (3346) 5.1 (4.2–6.0) 2746 7.4 (6.2–8.5) 1810 13.1 (11.1–15.0) 804 NA NA 31, 34, 52, 60, 61, 69, 75, 82, 87, 96, 98, 103, 112, 116, 136, 138, 170, 187, 212, 220, 229, 241, 290, 299, 311, 344, 399, 414, 417436
Pit picking (5432) 2.8 (2.4–3.3) 5221 6.6* (5.9–7.4) 1962* 14.2 (12.5–15.9) 1401 NA NA 16, 22, 55, 69, 109, 193, 216, 278, 298, 309, 437452
Flaps (3073) 0.3 (0.1–0.5) 2902 1.1* (0.7–1.5) 1687* 6.4* (4.9–8.0) 708* NA NA 91, 98, 100, 108, 135, 173, 185, 191, 193, 227, 309, 322, 343, 362, 369, 375, 379, 424, 434, 453488
Incision and drainage (293) 6.3* (3.2–9.3) 259* 22.3 (15.8–28.9) 243 36.8* (26.3–47.2) 121* NA NA 20, 52, 55, 77, 184, 212, 223, 253, 489
Phenol only (1453) 1.6* (0.9–2.3) 1244* 14.7 (12.1–17.3) 687 NA NA NA NA 53, 76, 114, 242, 363, 385, 490505
Laser treatment (77) 2.2* (0.0–4.8) 74* 11.8* (0.8–22.9) 47* NA NA NA NA 506508
Others (1363) 2.8 (1.9–3.8) 1247 6.6* (4.8–8.4) 624* 19.8 (15.7–23.8) 498 NA NA 15, 16, 309, 430, 489, 509523
Partial closure (202) 0.6* (0.0–1.4) 202* 1.1* (0.0–2.5) 201* 11.2* (5.9–16.6) 161* NA NA 62, 98, 143