Table 2.
Univariate and multivariate analyses of various potential prognostic factors for LC, FFNR and OS in patients with sebaceous carcinoma of the eyelid treated with radiotherapy
| No. | 7-year LC | 7-year FFNR | 7-year OS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UVA | MVA | UVA | MVA | UVA | MVA | ||||||||
| Rate (%) | P value | HR (95 %CI) | P value | Rate (%) | P value | HR (95 %CI) | P value | Rate (%) | P value | HR (95 %CI) | P value | ||
| PS | 0.439 | − | − | 0.925 | − | − | 0.629 | 2.861 | 0.059 | ||||
| 0–1 | 76 | 53.8 | 75.5 | 84.3 | (0.959–8.537) | ||||||||
| 2–3 | 7 | 34.3 | 80.0 | 66.7 | |||||||||
| Sex | 0.141 | − | − | 0.201 | − | − | 0.065 | 0.431 | 0.217 | ||||
| Female | 46 | 57.7 | 81.8 | 89.5 | (0.113–1.638) | ||||||||
| Male | 37 | 45.2 | 67.5 | 76.5 | |||||||||
| Age | 0.577 | − | − | 0.475 | − | − | 0.012 | 1.251 | 0.010 | ||||
| <70 | 49 | 56.5 | 77.6 | 90.5 | (1.055–1.484) | ||||||||
| ≥70 | 34 | 45.4 | 73.3 | 71.7 | |||||||||
| T stage (UICC 6th) | 0.232 | 0.972 | 0.948 | 0.134 | 1.821 | 0.305 | 0.224 | 2.033 | 0.200 | ||||
| T1 (≤5 mm) | 7 | 66.7 | (0.415–2.274) | 100 | (0.579–5.729) | 100 | (0.686–6.020) | ||||||
| T2 (5–10 mm) | 30 | 56.0 | 85.8 | 89.8 | |||||||||
| T3 (>10 mm) | 38 | 44.1 | 66.5 | 74.2 | |||||||||
| T4 | 8 | 56.3 | 35.0 | 87.5 | |||||||||
| Tumor size | 0.054 | 1.031 | 0.332 | 0.037 | 1.014 | 0.758 | 0.051 | 1.148 | 0.286 | ||||
| ≤10 mm | 37 | 58.8 | (0.969–1.098) | 88.4 | (0.928–1.108) | 92.2 | (0.891–1.481) | ||||||
| >10 mm (including T4) | 46 | 46.6 | 63.3 | 76.1 | |||||||||
| RT dose (EQD2 Gy) | 0.537 | 0.930 | 0.882 | 0.926 | 1.943 | 0.524 | 0.506 | 3.941 | 0.300 | ||||
| ≥60 Gy | 73 | 52.4 | (0.353–2.445) | 74.7 | (0.252–14.976) | 83.0 | (0.294–52.768) | ||||||
| <60 Gy | 10 | 50.0 | 80.0 | 87.5 | |||||||||
| Indication for RT | 0.719 | 1.142 | 0.583 | 0.310 | 1.156 | 0.658 | 0.521 | 0.662 | 0.493 | ||||
| Initial treatment | 65 | 51.1 | (0.712–1.831) | 77.9 | (0.608–2.197) | 86.5 | (0.204–2.151) | ||||||
| Salvage RT | 11 | 51.9 | 77.1 | 76.2 | |||||||||
| Adjuvant RT | 7 | 71.4 | 51.4 | 68.6 | |||||||||
EQD2 Gy = equivalent dose in 2 Gy, FFNR = freedom from neck lymph node recurrence, HR = hazard ratio, LC = local control, MVA = multivariate analysis, OS = overall survival, PS = performance status, RT = radiation therapy, UVA = univariate analysis.