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. 2019 Oct 22;10(5):e02059-19. doi: 10.1128/mBio.02059-19

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FIG 1 — Oseltamivir treatment. (a) Experimental design. Four animals (PRE1 to PRE4) were treated with a single dose of oseltamivir phosphate (150 mg) starting 24 h before infection, 4 animals (POST1 to POST4) were treated with oseltamivir starting 24 h postinfection, and 2 animals (CTRL1 and CTRL2) served as controls and were treated with PBS. Treatment was continued for a total of 5 consecutive days. All animals were challenged with the 1918 influenza virus (total, 7 × 10⁶ PFU) by four different routes. (b) Survival curve. Both controls (CTRL1 and CTRL2) and one posttreated animal (POST1) had to be euthanized on 8 and 9 dpi. All other treated animals developed mild to moderate/severe clinical symptoms but survived. Four untreated controls were added from a separate experiment (historical controls [hCTRL]) (6).