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. 2019 Oct 22;9:15110. doi: 10.1038/s41598-019-51756-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lateral Inhibition and GJ Mediated Signaling Considerably Alter RGC Response Delays. (a) Representative RGC responses (to the left) in control conditions (blue) and after a GJ blockade (red; MFA 40 μM concentration). Histogram in the middle displays MFA induced changes of PSTH-based response delays for the examined RGC population (n = 159; ON/OFF:107/52). Diagram to the right shows a reduction in the RGC response delay range due to MFA application. Response delay changes were calculated as (delay_control-delay_mfa)/delay_control * 100). (b) RGC light responses in control conditions (blue) and after a GJ blockade (red; MFA 40 μM concentration; left panel). Histogram in the middle displays MFA induced changes of Ca⁺⁺-transient light response delays for the examined RGC population (n = 95); and diagram to the right shows the reduction of RGC response latency range following MFA application. (delay_control-delay_mfa)/delay_control * 100). (c) Representative RGC responses in control conditions (blue) and under the blockade of GABA-ergic signaling (red; PTX 50μM concentration). Histogram in the middle displays PTX induced changes of PSTH based response delays for the examined RGC population (n = 31). Diagram to the right shows the GABA blockade induced changes of RGC response delays and also the reduction of the delay range induced by PTX application. Response delay changes were calculated as (delay_control-delay_ptx)/delay_control * 100). (d) RGC Ca⁺⁺-transient light responses in control conditions (blue) and after following PTX incubation (red; PTX, 50 μM concentration). Histogram displays PTX-induced changes in Ca⁺⁺-transient light response delays for the examined RGC population (n = 83; middle panel), while the diagram to the right shows the reduction in the latency range induced by the pharmacological intervention. Response delay changes were calculated as (delay_control-delay_ptx)/delay_control * 100.