2. Estimated response rates per dose and percentage difference in responders per dose compared to placebo.

Dose (mg)	Fitted response rate (%)	95% CI		Dose (mg)	Difference in response rate from placebo (%)	95% CI
		Lower	Upper			Lower	Upper
Placebo	17.8	6.3	29.4
200	37.6	20.2	55.0	200	19.7	‐1.2	40.6
300	38.1	‐28.1	104.2	300	20.2	‐46.9	87.3
400	37.5	7.8	67.3	400	19.7	‐12.2	51.6
450	38.1	‐16.1	92.4	450	20.3	‐35.2	75.8
600	42.2	23.5	61.0	600	24.4	2.4	46.5
800	42.2	13.8	70.6	800	24.4	‐6.3	55.1
1000	51.1	29.5	72.7	1000	33.3	8.8	57.8

CI: confidence intervals