Table 2.

Associations of BMI and NT‐proBNP With Incident AF in the ARIC Cohort (n=9556)

	BMI<30 and Low NT‐proBNP	BMI≥30 and Low NT‐proBNP	BMI<30 and High NT‐proBNP	BMI≥30 and High NT‐proBNP	Interaction P Value
No. of AF events	343	292	724	447
Participants, n (%)	3074 (32.2)	1841 (19.3)	3167 (33.1)	1474 (15.4)
Person‐years	51 493	29 970	46 731	20 937
NT‐proBNP less than or greater than or equal to median <68.2 pg/mL, HR (95% CI)*
Model 1b	Ref	1.69 (1.45–1.98)	2.37 (2.07–2.71)	3.64 (3.15–4.22)	0.34
Model 2c	Ref	1.56 (1.33–1.83)	2.11 (1.84–2.42)	3.04 (2.62–3.54)	0.46
NT‐proBNP <125 pg/mL or ≥125 pg/mL, HR (95% CI)a
Model 1b	Ref	1.63 (1.44–1.85)	2.35 (2.07–2.66)	3.51 (3.03–4.06)	0.37
Model 2c	Ref	1.51 (1.33–1.71)	2.02 (1.78–3.00)	2.87 (2.47–3.35)	0.21

AF indicates atrial fibrillation; ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; HR, hazard ratio; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; ref, reference.

^aHRs are for associations of BMI categories and pro‐BNP levels, with AF.

^bModel 1, adjusted for age, sex, race/center, and education.

^cModel 2, adjusted for age, sex, center, race, standing height, smoking, education, drinking, diabetes mellitus, myocardial infarction, aspirin, statin, hypnotic drugs, left ventricular hypertrophy by Cornell definition, P‐wave terminal force in lead V₁, systolic blood pressure.