TABLE A4.

Outcome Measures Reported by Treatment Strategy and Study^a

First Author	Subcategory	Methodology	Sports Activity	Time to RTS	Tegner Score	FAOS Score	FAAM Score	FADI Score	Karlsson Score	FFI-D Score	Valderrabano Score	Martin Score	AAS Score
BMS
Ogilvie-Harris58	BMS	PCS										x
Bonnin6	BMS	RCS			x				x
Kumai43	BMS	RCS	x
Ogilvie-Harris59	BMS	RCS	x									x
Ogilvie-Harris60	BMS	RCS	x									x
Draper17	BMS	R Comp	x
Savva75	BMS	RCS	x
Ferkel20	BMS	RCS	x
Ventura94	BMS	RCS		x	x
Dunlap18	BMS	RCS	x
van Bergen88	BMS	RCS	x
Kramer41	BMS	RCS	x	x		x
Karnovsky35	BMS	R Comp				x
Lee47	BMS	R Cohort				x
Reilingh69	BMS + PEMF	RCT	x	x									x
van Eekeren92	BMS	RCS	x			x							x
Kim38	BMS + PRP/MSC	R Comp		x	x
Sun85	BMS	RCT			x
Guney26	BMS + PRP/MSC	RCT					x
Hankemeier29	BMS	RCS	x
Murphy54	BMS	P Comp				x
Saxena76	BMS	P Comp	x	x
Domayer15	BMS	PCS	x
Internal fixation
Kumai44	Drilling + fixation	RCS	x
Schuh77	Drilling + fixation	RCS	x
Retrograde drilling
Rosenberger72	Retrograde drilling	RCS				x
Osteo(chondral) transplantation
Saxena76	Autograft	PCS	x	x
Sun85	Autograft	RCT			x
Draper17	Autograft	R Comp	x
Lee46	Autograft	RCS	x
Haasper27	Mosaicplasty	RCS	x
Valderrabano86	Mosaicplasty	RCS	x								x
Hangody28	Mosaicplasty	PCS	x
Kennedy36	Autograft	PCS	x	x
Paul63	Autograft	RCS	x		x
Pearce64	Synthetic graft	PCS	x
Hu32	Osteoperiosteal graft	RCS	x
Leumann48	Mosaicplasty	PCS	x
Petersen65	Autograft	PCS	x		x
Ahmad1	Autograft/allograft	RCT					x
Fraser21	Autograft	RCS	x	x
Hintermann31	Autograft	PCS	x	x
Zhu98	Autograft + allograft	RCS	x
Kim39	Autograft	RCS			x
Gautier22	Autograft	RCS	x
Ogut61	Autograft	RCS	x
DeSandis13	Synthetic graft	RCS				x
Cartilage implantation
Baums4	ACI	PCS	x
Giannini23	ACI	PCS	x
Giannini24	ACI	RCS	x
Aurich3	MACI	PCS	x
Magnan51	ACI	RCS	x
Coetzee9	ACI	RCS	x
Nehrer55	MACI/ACI	PCS					x
Dekker12	PJCI	RCS	x
Metal implantation
Ettinger19	Metal implant	RCS	x
Vuurberg96	Metal implant	PCS				x
Chondrogenesis-inducing techniques
Valderrabano87	AMIC	PCS	x
Kubosch42	AMIC	PCS	x
Gottschalk25	AMIC	P Cohort								x
Clanton8	Other	RCS						x
Pagliazzi62	Other	RCS	x
Murphy54	Other	P Cohort				x
Richter71	Other	PCS	x
Karnovsky35	Other	RCS				x
Sadlik74	Other	P Comp	x

^aAs there were several studies that reported outcomes for multiple treatment options (ie, comparative study), the total number of treatment strategies is higher than the total number of included studies. AAS, Ankle Activity Score; ACI, autologous chondrocyte implantation; AMIC, autologous matrix-induced chondrogenesis; BMS, bone marrow stimulation; FAAM, Foot and Ankle Ability Measure; FADI, Foot and Ankle Disability Index; FAOS, Foot and Ankle Outcome Score; FFI-D, German Foot Function Index; MACI, matrix-induced autologous chondrocyte implantation; MSC, mesenchymal stem cell; P Cohort, prospective cohort study; P Comp, prospective comparative study; PCS, prospective case series; PEMF, pulsed electromagnetic field; PJCI, particulated juvenile cartilage implantation; PRP, platelet-rich plasma; R Cohort, retrospective cohort study; R Comp, retrospective comparative study; RCS, retrospective case series; RCT, randomized controlled trial; RTS, return to sports.