Figure 2.

(a) Spectral interrogation of nanophotonic sensors. In this representative schematic a collinear light-path is shown, where broadband illumination excites the localized surface plasmons creating a resonance peak in transmission spectrum. The red-shift in the spectral position of the resonance peak can be monitored to extract quantitative analyte binding information; (b) Single-point spectroscopy in a bright-field transmission configuration was used to interrogate a nanoplasmonic sensor for the detection of an Alzheimer biomarker. Reprinted with permission from [48]. Copyright 2005 American Chemical Society; (c) Single-point spectroscopy in a dark-field transmission configuration was used to interrogate short-range ordered nanoholes. Adapted with permission from [50]. Copyright 2005 American Chemical Society.