Table 2.
Coronary computed tomography angiography findings at baseline and follow-up
| Non-statin group (n = 246) |
Statin-taking group (n = 408) |
P between groups |
||||
|---|---|---|---|---|---|---|
| Baseline | FU | Baseline | FU | Baseline | FU | |
| Coronary artery calcium scan | ||||||
| Total Agatston CACS | 58.8 ± 231.4 | 115.2 ± 426.2 | 146.2 ± 381.7 | 252.1 ± 530.5 | <0.001 | <0.001 |
| 0 (0, 30) | 6 (0, 72) | 29 (0, 128) | 62 (0, 254) | |||
| Agatston CACS category, n (%) | ||||||
| 0 | 132 (53.7) | 106 (43.1) | 138 (33.8) | 104 (25.5) | <0.001 | <0.001 |
| 1–99 | 82 (33.3) | 92 (37.4) | 153 (37.5) | 122 (29.9) | ||
| 100–399 | 26 (10.6) | 33 (13.4) | 79 (19.4) | 111 (27.2) | ||
| ≥400 | 6 (2.4) | 15 (6.1) | 38 (9.3) | 71 (17.4) | ||
| Quantitative CCTA analysis—normalized PVs (mm3) | ||||||
| Total PV | 70.0 ± 141.6 | 115.4 ± 206.4 | 142.3 ± 237.1 | 218.2 ± 319.2 | <0.001 | <0.001 |
| Calcified PV | 20.2 ± 68.6 | 42.5 ± 109.4 | 51.0 ± 131.6 | 103.7 ± 210.5 | <0.001 | <0.001 |
| Non-calcified PV | 49.8 ± 89.2 | 73.0 ± 122.7 | 91.3 ± 139.4 | 114.6 ± 157.0 | <0.001 | <0.001 |
| Fibrous PV | 31.7 ± 61.9 | 50.1 ± 84.6 | 62.5 ± 105.3 | 85.6 ± 118.9 | <0.001 | <0.001 |
| Fibrous-fatty PV | 16.2 ± 32.2 | 20.3 ± 42.8 | 25.3 ± 40.8 | 25.8 ± 44.9 | 0.002 | 0.122 |
| Lipid-rich PV | 1.9 ± 4.9 | 2.6 ± 7.5 | 3.6 ± 8.3 | 3.2 ± 8.8 | 0.001 | 0.324 |
| Annualized change in coronary artery calcium scan | ||||||
| Agatston CACS, /year | 14.6 ± 44.0 | 27.5 ± 50.8 | <0.001 | |||
| Annualized change in normalized PVs (mm3/year) | ||||||
| Total PV | 13.0 ± 21.7 | 20.2 ± 29.1 | <0.001 | |||
| Calcified PV | 6.0 ± 12.9 | 13.8 ± 25.7 | <0.001 | |||
| Non-calcified PV | 7.0 ± 17.3 | 6.4 ± 22.8 | 0.702 | |||
| Fibrous PV | 5.5 ± 11.9 | 6.2 ± 16.6 | 0.558 | |||
| Fibrous-fatty PV | 1.3 ± 8.4 | 0.3 ± 9.5 | 0.168 | |||
| Lipid-rich PV | 0.2 ± 1.8 | −0.06 ± 2.06 | 0.073 | |||
CACS, coronary artery calcium score; CCTA, coronary computed tomography angiography; FU, follow-up; PV, plaque volume.