. 2019 Apr 12;20(11):1239–1247. doi: 10.1093/ehjci/jez070

Table 4.

Predictive values for CIMT, MPH, TPA, and IPN when used to predict CAD

Variables (N = 459)	AUC	Cut-off	Significant CAD		Non-significant CAD		PPV (%)	NPV (%)	Sens (%)	Spec (%)	LR+ (%)	LR− (%)
A. For predicting (≥50% stenosis)
CIMT	0.625	≥0.80 mm	TP	132	FP	43	75	46	46	75	189	71
		<0.80 mm	FN	152	TN	132	75	46	46	75	189	71
MPH	0.661	≥2.41 mm	TP	186	FP	72	72	51	65	59	159	59
		<2.41 mm	FN	98	TN	103	72	51	65	59	159	59
TPA	0.665	≥27.6 mm²	TP	216	FP	83	72	58	76	53	160	46
		<27.6 mm²	FN	68	TN	92	72	58	76	53	160	46
aIPN	0.94	≥1.25	TP	260	FP	20	93	87	92	89	801	10
		<1.25	FN	24	TN	155	93	87	92	89	801	10
B. For predicting severe CAD (≥70% stenosis)
CIMT	0.603	≥0.75 mm	TP	137	FP	85	62	55	56	61	143	72
		<0.75 mm	FN	106	TN	131	62	55	56	61	143	72
MPH	0.643	≥2.42 mm	TP	161	FP	94	63	60	66	56	152	60
		<2.42 mm	FN	82	TN	122	63	60	66	56	152	60
TPA	0.667	≥24.8 mm²	TP	201	FP	117	63	70	83	46	153	38
		<24.8 mm²	FN	42	TN	99	63	70	83	46	153	38
aIPN	0.853	≥1.25	TP	224	FP	56	80	89	92	74	356	11
		<1.25	FN	19	TN	160	80	89	92	74	356	11

aIPN, average intraplaque neovascularization; AUC, area under the curve; CIMT, carotid intima-media thickness; FN, false negatives; FP, false positives; LR−, negative likelihood ratio; LR+, positive likelihood ratio; MPH, maximum plaque height; NPV, negative predictive value; PPV, positive predictive value; sens, sensitivity; spec, specificity; TN, true negatives; TP, true positives; TPA, total plaque area.