Figure 1.
NNC0165-1273 reduces nighttime and ghrelin-induced feeding. The effect of 0, 0.04, 0.2 and 1 µmol/kg NN on cumulative (A) normal, nighttime feeding and (B) ghrelin-induced feeding during the light phase. NN was injected 30 minutes before lights out or concomitantly with ghrelin at 2 hours after lights on. (C) To compare the relative potency of NN and PYY3-36, lower doses of the peptides were injected SC and nighttime food intake measured. Data presented as mean ± SEM. Two-way ANOVA with Tukey post hoc tests: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. NN, NNC0165-1273.