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. 2019 Oct 4;23(10):496–507. doi: 10.1089/omi.2019.0122

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© Marelize Swart and Collet Dandara, 2019. Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 2. — Effects of efavirenz and rifampicin on mRNA expression of genes coding for drug-metabolizing enzymes or nuclear receptors in HepaRG cells (average of three biological replicates) relative to TBP as reference gene. Differentiated HepaRG cells were treated with efavirenz (6.4 μM), rifampicin (24.4 μM), or DMSO (0.02%) for 24 h. Expression of mRNA for genes coding for drug-metabolizing enzymes or nuclear receptors, in triplicate, were assessed by using qPCR and the fold change in mRNA expression is compared for each treatment condition. Significant (p < 0.05) changes in mRNA expression are indicated with *.