Table 2.
Pharmacokinetic parameters of MK-801 after s.c. or i.p. administration in brain tissue and blood plasma.
| Administration route | Brain tissue |
Blood plasma |
||
|---|---|---|---|---|
| Cmax (ng/g) | AUC (ng min/g) | Cmax (ng/ml) | AUC (ng min/ml) | |
| s.c., 0.1 mg/kg | 90.4 ± 5.6 | 5940 ± 196* | 5.0 ± 0.5 | 311 ± 8* |
| i.p., 0.1 mg/kg | 46.3 ± 1.1 | 3733 ± 123 | 2.7 ± 0.2 | 208 ± 9 |
Cmax — maximal concentration; s.c. — subcutaneous; i.p. — intraperitoneal; AUC — area under the curve was calculated from 15 min to 240 min after drug administration. Each point represents the mean (± SEM) of three mice per group. The data were analyzed for significant differences using unpaired Student’s t-test. *p < 0.05 vs. the corresponding i.p. group.