Table 3. Pregnancy Outcomes Based on Conception Interval After Surgery or RAIT and Cumulative RAI Dose.
| Pregnancy Outcome | Surgery Cohort, No. (%) | RAIT Cohort, No. (%) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Conception Interval After Surgery, mo | Conception Interval After RAIT, mo | Cumulative RAI Dose, GBq | ||||||||||||
| 0-5 | 6-11 | 12-23 | ≥24 | P Value | 0-5 | 6-11 | 12-23 | ≥24 | P Value | ≤1.11 (n = 10 315) | 1.12-3.7 (n = 16 477) | ≥3.8 (n = 25 184) | P Value | |
| Pregnancies | 1187 | 1150 | 1559 | 2062 | NA | 358 | 710 | 1819 | 1997 | NA | 807 | 1325 | 2752 | NA |
| Abortions, No. (% of pregnancies) | 355 (29.9) | 345 (30.0) | 468 (30.0) | 661 (32.1) | .43 | 217 (60.6) | 214 (30.1) | 499 (27.4) | 638 (31.9) | <.001 | 260 (32.2) | 443 (33.4) | 865 (31.4) | .44 |
| Preterm deliveries, No. (% of deliveries) | 79 (9.5) | 93 (11.6) | 133 (12.2) | 224 (16.0) | <.001 | 15 (10.6) | 61 (12.3) | 149 (11.3) | 202(14.9) | .04 | 82 (15.0) | 107 (12.1) | 238 (12.6) | .26 |
| Deliveries | 832 (70.1) | 805 (70.0) | 1091 (70.0) | 1401 (67.9) | .43 | 141 (39.4) | 496 (69.9) | 1320 (72.6) | 1359 (68.1) | <.001 | 547 (67.8) | 882 (66.6) | 1887 (68.6) | .44 |
| Mother-infant pairs | 792 | 762 | 1030 | 1346 | .23 | 135 | 471 | 1264 | 1296 | .89 | 525 | 846 | 1795 | .53 |
| Congenital malformations, No. (% of mother-infant pairs) | 67 (8.5) | 58 (7.6) | 103 (10.0) | 121 (9.0) | .35 | 18 (13.3) | 37 (7.9) | 105 (8.3) | 125 (9.6) | .16 | 45 (8.6) | 76 (9.0) | 164 (9.1) | .92 |
| Nervous system | 2 (0.3) | 0 | 4 (0.4) | 3 (0.2) | NA | 1 (0.7) | 2 (0.4) | 3 (0.2) | 7 (0.5) | NA | 5 (1.0) | 0 | 8 (0.4) | NA |
| Eye, ear, face and neck | 3 (0.4) | 3 (0.4) | 4 (0.4) | 4 (0.3) | 0 | 5 (1.1) | 7 (0.6) | 5 (0.4) | 7 (1.3) | 1 (0.1) | 9 (0.5) | |||
| Circulatory system | 23 (2.9) | 18 (2.4) | 40 (3.9) | 43 (3.2) | 6 (4.4) | 12 (2.5) | 40 (3.2) | 43 (3.3) | 14 (2.7) | 32 (3.8) | 55 (3.1) | |||
| Respiratory system | 3 (0.4) | 3 (0.4) | 5 (0.5) | 2 (0.1) | 1 (0.7) | 0 | 3 (0.2) | 1 (0.1) | 1 (0.2) | 2 (0.2) | 2 (0.1) | |||
| Cleft lip and cleft palate | 0 | 0 | 3 (0.3) | 3 (0.2) | 1 (0.7) | 0 | 3 (0.2) | 2 (0.2) | 0 | 3 (0.4) | 3 (0.2) | |||
| Other digestive system | 6 (0.8) | 2 (0.3) | 2 (0.2) | 3 (0.2) | 0 | 3 (0.6) | 4 (0.3) | 7 (0.5) | 2 (0.4) | 2 (0.2) | 10 (0.6) | |||
| Genital organs | 2 (0.3) | 6 (0.8) | 6 (0.6) | 6 (0.4) | 1 (0.7) | 3 (0.6) | 10 (0.8) | 12 (0.9) | 3 (0.6) | 6 (0.7) | 17 (0.9) | |||
| Urinary system | 6 (0.8) | 5 (0.7) | 11 (1.1) | 14 (1.0) | 3 (2.2) | 2 (0 .4) | 5 (0.4) | 15 (1.2) | 5 (1.0) | 5 (0.6) | 15 (0.8) | |||
| Musculoskeletal system | 20 (2.5) | 20 (2.6) | 27 (2.6) | 43 (3.2) | 4 (3.0) | 13 (2.8) | 36 (2.8) | 35 (2.7) | 14 (2.7) | 25 (3.0) | 49 (2.7) | |||
| Other malformation | 3 (0.4) | 3 (0.4) | 5 (0.5) | 14 (1.0) | 2 (1.5) | 3 (0.6) | 6 (0.5) | 9 (0.7) | 2 (0.4) | 4 (0.5) | 14 (0.8) | |||
Abbreviations: RAI, radioactive iodine (sodium iodide I 131, or Na131I); RAIT, radioactive iodine treatment.