Table 4. Multivariate Analysis of Risk Factors Associated With Adverse Pregnancy Outcomes in Women Receiving RAIT.
| Risk Factor | Abortion | Preterm Delivery | Congenital Malformation | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Cumulative RAI dose, GBq | ||||||
| ≤1.11 [Reference] | NA | NA | NA | NA | NA | NA |
| 1.12-3.7 | 1.11 (0.91-1.36) | .30 | 0.79 (0.58-1.08) | .14 | 1.06 (0.72-1.56) | .76 |
| ≥3.8 | 1.02 (0.85-1.22) | .81 | 0.82 (0.63-1.08) | .16 | 1.08 (0.76-1.52) | .68 |
| Conception interval after RAIT, mo | ||||||
| 0-5 | 4.08 (3.19-5.22) | <.001 | 0.92 (0.53-1.62) | .78 | 1.74 (1.01-2.97) | .04 |
| 6-11 | 1.16 (0.95-1.42) | .14 | 1.10 (0.80-1.51) | .57 | 0.95 (0.64-1.41) | .80 |
| 12-23 [Reference] | NA | NA | NA | NA | NA | NA |
| ≥24 | 1.08 (0.93-1.25) | .31 | 1.34 (1.07-1.69) | .01 | 1.17 (0.89-1.54) | .26 |
| Age at conception, y | ||||||
| 20-29 [Reference] | NA | NA | NA | NA | NA | NA |
| 30-34 | 1.17 (0.97-1.40) | .10 | 0.97 (0.74-1.27) | .83 | 1.27 (0.91-1.76) | .16 |
| 35-39 | 2.11 (1.73-2.56) | <.001 | 1.22 (0.90-1.64) | .20 | 1.28 (0.88-1.86) | .19 |
| ≥40 | 10.61 (8.05-13.96) | <.001 | 1.22 (0.68-2.17) | .51 | 1.39 (0.60-3.22) | .44 |
Abbreviations: NA, not applicable; OR, odds ratio; RAI, radioactive iodine (sodium iodide I 131, or Na131I); RAIT, radioactive iodine treatment.