. 2019 Oct 16;2(10):e1913491. doi: 10.1001/jamanetworkopen.2019.13491

Table 3. Variants Identified Predominantly in Participants With the Greatest Unexplained Intergenerational Variability in AAO of Alzheimer Disease^a .

Z Score of Residuals	Gene (Variant) [Amino Acid Position]	Mean Residual (Range)^b
<−1 SD, earlier-than-expected offspring AAO	GRN (42429501:G:A) [p.Arg433Gln]	−1.63
	MAPT (44061123:C:T) [p.Ser318Leu]	−1.56 (−2.27 to −0.77)
	PLD3 (408758:G:A) [p.Val159Met]	−1.38
	PSEN1 (73673178:A:G) [p.Glu318Gly]	−1.04 (−2.13 to 0.64)
>1 SD, later-than-expected offspring AAO	GRN (42429835:G:A) [p.Val514Met]	1.49
	C9orf72^c	1.34
	PSEN2 (A346S)	1.32
	PLD3 (40877595:G:A) [p.Val232Met]	1.31
	APP (V287G)	1.11

Abbreviation: AAO, age at symptomatic onset.

^{^a}

Residual values from the model were normalized; high variability was defined as a Z score of residual SD less than −1 or greater than 1.

^{^b}

Items without a range were reported in only 1 participant.

^{^c}

Twenty-nine repeats.

Table 3. Variants Identified Predominantly in Participants With the Greatest Unexplained Intergenerational Variability in AAO of Alzheimer Diseasea .