Association of reported number of nocturnal awakenings in a typical night with total brain Aβ deposition (B = 0.041; 95% CI, 0.015 to 0.067; P = .003) (A), association of nocturnal awakenings with Aβ deposition in the precuneus (B = 0.11; 95% CI, 0.06 to 0.17; P < .001) (B), association of nocturnal awakenings with MMSE scores (B = −2.13; 95% CI, −3.13 to −1.13; P < .001) (C), and association of Aβ deposition in the precuneus with MMSE scores (B = −5.54; 95% CI, −10.24 to −0.85; P = .02) (D) are shown. Data points represent individual patients. Trendlines indicate significant regressions. SUVR indicates standardized uptake value ratio.