Table 1.
Descriptive characteristics of GENOA African Americans
| Characteristic | Non-Missing N | Mean (SD) or % |
|---|---|---|
| Age at Phase I (years) | 1390 | 58.0 (10.1) |
| DNAm age at Phase I (years) | 1390 | 55.0 (9.9) |
| IEAA | 1389 | 0.1 (4.8) |
| EEAA | 1390 | 0.2 (5.8) |
| Time between Phases I and II | 1390 | 5.1 (1.3) |
| Sex | 1390 | |
| Male | 28.9% | |
| Female | 71.1% | |
| Smoking | 1390 | |
| Never | 60.2% | |
| Former | 27.6% | |
| Current | 12.2% | |
| BMI (kg/m2) | 1390 | 31.7 (6.7) |
| Systolic BP (mmHg) | 1390 | 138.5 (20.8) |
| Diastolic BP (mmHg) | 1390 | 79.5 (10.9) |
| Antihypertensive use | 1390 | |
| No | 29.2% | |
| Yes | 70.8% | |
| Diabetes | 1390 | |
| No | 69.7% | |
| Yes | 30.3% | |
| Albuminuria (mg/g) | 1390 | |
| Normal | 81.7% | |
| Microa | 14.3% | |
| Macrob | 4.0% | |
| eGFR (mL/min/1.73m2) | 1390 | 88.9 (21.0) |
| UACR (mg/g) | 1390 | 68.4 (352.9) |
| RWT | 1352 | 0.3 (0.1) |
| LVMI (g/m2.7) | 1346 | 39.3 (10.4) |
| ABI | 1359 | 1.0 (0.1) |
| WMH (cm3)c | 758 | 10.6 (11.6) |
| TIV (cm3)c | 766 | 1373.9 (135.8) |
Abbreviations: IEAA Intrinsic epigenetic age acceleration, EEAA Extrinsic epigenetic age acceleration, BMI Body mass index, BP Blood pressure, TIV Total intracranial volume, eGFR Estimated glomerular filtration rate, UACR Urinary albumin to creatinine ratio, LVMI Left ventricular mass index, RWT Relative wall thickness, ABI Ankle-brachial index, WMH White matter hyperintensity, TIV Total intracranial volume
aMicroalbuminuria is defined as 30 mg/g ≤ UACR < 300 mg/g
bMacroalbuminuria is defined as UACR ≥300 mg/g
cWMH and TIV were measured an average of 6.3 years after Phase I
All measures were taken at Phase II unless otherwise noted