. 2019 Oct 22;12:141. doi: 10.1186/s12920-019-0585-5

Table 3.

Phenotypic, genetic, and environmental correlations between epigenetic age acceleration and target organ damage measures among GENOA African Americans

Target organ damage	Epigenetic age accleration	Model	h² TOD	h² EAA	ρ_P	ρ_G	ρ_E
UACR^a	IEAA	1	0.383^***	0.484^***	0.067^*	−0.075	0.176^*
UACR^a	IEAA	2	0.376^***	0.510^***	0.056^*	0.066	0.050
RWT	IEAA	1	0.265^***	0.483^***	0.060^*	0.001	0.097
RWT	IEAA	2	0.246^***	0.510^***	0.056^*	0.086	0.042
LVMI	IEAA	1	0.563^***	0.480^***	0.064^*	−0.032	0.168
	EEAA	1	0.566^***	0.604^***	0.062^*	−0.056	0.229^†
		2	0.506^***	0.601^***	0.066^*	−0.005	0.155
		3	0.440^***	0.604^***	0.056^*	−0.022	0.144
ABI	IEAA	1	0.354^***	0.483^***	−0.074^**	−0.004	− 0.125
ABI	IEAA	2	0.355^***	0.510^***	−0.067^*	−0.037	− 0.092

Abbreviations: IEAA Intrinsic epigenetic age acceleration, EEAA Extrinsic epigenetic age acceleration, UACR Urinary albumin to creatinine ratio, RWT Relative wall thickness, LVMI Left ventricular mass index, ABI Ankle-brachial index, h² Heritability estimate, ρ_P Phenotypic correlation, ρ_G Genetic correlation, ρ_E = environmental correlation

Model 1 covariates: chronological age + sex + time between methylation and target organ damage measure

Model 2 covariates: Model 1 covariates + SBP + DBP + antihypertensive medication

Model 3 covariates: Model 2 covariates + smoking + diabetes + BMI + albuminuria

^aVariables were natural log transformed prior to analysis

^†p < 0.1, *p < 0.05, **p < 0.01, ***p < 0.001