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. 2019 Oct 23;26:84. doi: 10.1186/s12929-019-0567-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Tackling the hydrophilic guanidinium group in zanamivir and guanidine-oseltamivir carboxylate. a Using 1-hydroxy-2-naphthoic acid to form ion-pair. b Forming acylguanidine as prodrug