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. 2019 Oct 23;26:85. doi: 10.1186/s12929-019-0583-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — IT-101 induced activation of NK cells, which facilitates other immune cells to attack tumors. First immunization with IT-101 (CPT conjugated with CD-PEG) modulated the populations of neutrophil (Neu) and immature dendritic cells (iDC). Boosting with IT-101 induced affected NK cells to secrete IFNγ and TNFα. IFNγ promotes Th and Tc cell activation, and TNFα induces dendritic cell (DC) migration. Both NK and Tc cells generate and secrete perforin and granzyme to weaken and destroy tumor cells. Black lines indicate the results we suggested in this study. Gray lines indicate the results we predicted based on our results