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. 2019 Oct 22;7:272. doi: 10.1186/s40425-019-0730-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Immunoglobulin heavy chain analysis. a A high degree of IGHV SHM (SHM^high) was associated with significantly better overall survival (OS) in DLBCL overall and in DLBCL lacking BCL2 rearrangement (BCL2-R⁻) or MYC rearrangement (MYC-R⁻). b IGHV SHM^high was associated with significantly better OS and progression-free survival (PFS) in the training set, and significantly better OS in the BCL2-R⁻ cases of the validation set. c Short heavy chain complementarity determining region 3 (HCDR3) length was associated with significantly better OS in the germinal center B-cell-like (GCB)-DLBCL and overall DLBCL