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. 2019 Oct 22;7:272. doi: 10.1186/s40425-019-0730-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Prognostic analysis for IGHV ongoing SHM. a Schematic illustration of the putative pathologic origins of IGV SHM and ongoing SHM in DLBCL founder clones and subclones. Transformation can occur in different stages of B-cell development. When DLBCL abnormalities are sufficient to drive lymphomagenesis, DLBCL cells exit the germinal center reaction. Predominant DLBCL clones may exhibit intra-clonal IGV variations conferred by the ongoing SHM process. b IGHV ongoing SHM was associated with significantly poorer overall survival (OS) in the overall study cohort. c IGHV ongoing SHM was associated with poorer OS in the overall validation cohort and in cases without BCL2 rearrangement (BCL2-R⁻) in both the training and validation sets