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Schematic summary of the prognostic effects of IGV clonal SHM and ongoing SHM in DLBCL and putative underlying mechanisms suggested by in silico analysis and fluorescent multiplex immunohistochemistry and conventional chromogenic immunohistochemistry experiments. Abbreviations: Ig, immunoglobulin protein; AID, activation-induced cytidine deaminase; CSR, class-switch recombination; TCR, T-cell receptor; MHC, major histocompatibility complex; BCR, B-cell receptor; Mɸ, macrophage
