Fig. 4.
(A) Representative overlay of rat brain regions showing the distribution of Gd contrast agent in different specific regions after intranasal administration. (B) Nanoemulsion-Gd (NE-Gd) distribution at the time point of 25–30 minutes compared with Magnevist and control in specific regions of the brain. There was a significant decrease in T1 values for the NE-SA–treated group for different brain regions (*P < 0.05) compared with the control group. Student’s t tests were performed on the percentage change in T1 values for major brain regions and 172 specific brain regions of each subject. The t test statistics using a 95% (*P < 0.05) and 99% (**P < 0.001) confidence levels, two-tailed distributions, and heteroscedastic variance assumptions were performed. ctx, cortex.