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. 2019 Sep;370(3):504–513. doi: 10.1124/jpet.119.256941

Fig. 8.

Fig. 8.

Peripheral opioid receptor antagonist did not decrease TNBS-induced IL-1β mRNA expression. (A) IL-1β mRNA expression was not statistically different between 50-mg MP + TNBS + NAP and 50-mg MP + TNBS groups on day 4. N = 5/group; ns, not significant; ***P < 0.001 by two-way ANOVA with Tukey’s post hoc analysis. (B) Fluorometric quantification of FITC from blood serum showed a significant fluorescence concentration in all groups except for PP + VEH and PP + VEH + NAP groups. Daily NAP injection did not block membrane permeability in 50-mg MP + TNBS + NAP mice. N = 6 to 7; *P < 0.05 and **P < 0.01 by two-way ANOVA with Tukey’s post hoc analysis.