TABLE 3.
Summary of recent hydrogel technologies applied in drug delivery
| Drug | Hydrogel | Purpose | Reference |
|---|---|---|---|
| Insulin | Methyl β-cyclodextrin in polymethacrylic acid (PMAA) | Improve intestinal transport upon oral delivery | Sajeesh et al. (2010) |
| Insulin | Hydroxyethyl methacrylate (HEMA) | “do” | Wang et al. (2018) |
| Insulin | Carboxymethyl cellulose/poly(acrylic acid) | “do” | Gao et al. (2014) |
| Insulin and porcine growth hormone | Terpolymer hydrogels P((MAA-co-NVP)-g-EG) composed of methacrylic acid (MAA), N-vinyl pyrrolidone (NVP), and poly(ethylene glycol) (PEG) | “do” | O’Connor et al. (2017) |
| Dexamethasone | Guar gum (GG), poly(acrylic acid) (PAA) and cyclodextrin (CD) and tetraethyl orthosilicate as linker | Enhanced drug delivery | Das and Subuddhi (2015) |
| Salmon calcitonin | poly(itaconic acid-grafted-poly(ethylene glycol)) (P(IA-g-EG)) | Improve intestinal transport upon oral delivery | Koetting and Peppas (2014) |
| Hematological factor IX hFIX | poly(methacrylic acid)-grafted-poly(ethylene glycol) (P(MAA-g-EG)) (P(MAA-g-EG)) | Improve intestinal transport upon oral delivery | Horava et al. (2016) |
| Lidocaine | Chitosan with catechols and genipin cross linker | Rapid onset of action via buccal route | Xu et al. (2015) |
| Propranolol | Carboxymethyl cellulose and ZnO nanoparticles using Fe3+ ion as a crosslinking agent | Enhanced drug delivery | Zare-Akbari et al. (2016) |