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. 2019 Oct 21;77(1):49–57. doi: 10.1001/jamaneurol.2019.3531

Figure 3. Morphological Characteristics of the Interictal Epileptiform Discharges (IEDs).

Figure 3.

A, For each candidate IED, 5 fiducial points are identified (triangles) corresponding to the IED peak, troughs preceding and following the peak, peak of the after-going slow wave, and trough following the slow-wave peak. These feature values are used to construct a single multivariate logistic regression (MLR) model to evaluate binary IED scores for all experts combined (combined model) and individualized MLR models to evaluate the IED scores of individual experts (individualized models). B, Receiver operating characteristic curve for the MLR model fit to the scores of all experts (universal model). The operating point (false-positive rate = 1 − specificity and sensitivity) of each expert, corresponding to the threshold in the combined model that best evaluates that expert’s binary scores, is indicated by a solid circle. The number by each circle is the threshold that best evaluates that expert’s binary scores. A indicates the area under the IED curve; Ap, area under the peak; As, area under the slow wave; AUC, area under the curve; D, duration of the IED candidate wave; Dp, duration of the peak; Dpf, duration of the falling half-wave of peak; Dpr, duration of the rising half-wave of peak; Ds, duration of the slow wave; Dsf, duration of the falling half-wave of the slow wave; Dsr, duration of the rising half-wave of the slow wave; Ref, reference; Spf, slope of the falling half-wave of peak; Ssf, slope of the falling half-wave of the slow wave; Spr, slope of the rising half-wave of peak; Ssr, slope of the rising half-wave of the slow wave; Vp0, peak voltage with respect to baseline 0 defined by V = 0; Vp1, peak voltage with respect to baseline 1 defined by Von; Vp2, peak voltage with respect to baseline 2 defined by trough Vtr; Vs0, slow-wave peak voltage with respect to baseline 0 defined by V = 0; Vs1, slow-wave peak voltage with respect to baseline 1 defined by onset Von; Vs2, slow-wave peak voltage with respect to baseline 2 defined by trough Vtr; Vt0, trough voltage with respect to baseline 0 defined by V = 0; and Vt1, trough voltage with respect to baseline 1 defined by onset Von.