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. 2019 Oct 3;20:497–511. doi: 10.1016/j.isci.2019.10.006

Figure 6.

Figure 6

Inhibition of Tie2 Shedding, VE-PTP, and Tie1 Rescues Ang2-Induced Tie2 Activation

(A) Diagram of regulation mechanisms of Tie2 signaling: Tie2 shedding, VE-PTP action, and Tie1 binding.

(B) Effect of inhibition of VE-PTP, Tie1, and Tie2 cleavage on maximum phosphorylated Tie2 for 30 min post-stimulation.

(C) Effect of combination of inhibition of VE-PTP and Tie2 cleavage on maximum phosphorylated Tie2 for 30 min post-stimulation.

(D) Effect of combination of inhibition of VE-PTP and Tie1 on maximum phosphorylated Tie2 for 30 min post-stimulation.

(E) Effect of combination of inhibition of Tie1 and Tie2 cleavage on maximum phosphorylated Tie2 for 30 min post-stimulation.

See also Figure S2.