Table 3.
Genotype and Allele Frequencies of rs2274273 (C/T) and rs17128183 (A/G) Genetic Variants in Controls and Patients with Advanced CA, Divided by Gender
| Controls, n (%) | Patients, n (%) | P value | OR (95% CI) | |
|---|---|---|---|---|
| Males | ||||
| rs2274273 C/T | n = 165 | n = 294 | ||
| CC | 64 (38.79) | 120 (40.82) | 1 | |
| CT | 85 (51.52) | 133 (45.24) | 0.28 | 1.05 (0.79–1.40) |
| TT | 16 (9.70) | 41 (13.95) | 1.10 (0.62–1.96) | |
| Alleles | ||||
| C | 0.65 | 0.63 | ||
| T | 0.35 | 0.37 | 1.05 (0.71–1.56) | |
| rs17128183 A/G | n = 149 | n = 271 | ||
| AA | 53 (35.57) | 106 (39.11) | 1 | |
| AG | 80 (53.69) | 123 (45.39) | 0.20 | 1.03 (0.76–1.38) |
| GG | 16 (10.74) | 42 (15.5) | 1.05 (0.58–1.91) | |
| Alleles | ||||
| A | 0.62 | 0.62 | ||
| G | 0.38 | 0.38 | 1.03 (0.68–1.55) | |
| Females | ||||
| rs2274273 C/T | n = 135 | n = 191 | ||
| CC | 59 (43.7) | 83 (43.46) | 1 | |
| CT | 64 (47.41) | 87 (45.55) | 0.82 | 1.06 (0.75–1.48) |
| TT | 12 (8.89) | 21 (10.99) | 1.12 (0.57–2.20) | |
| Alleles | ||||
| C | 0.67 | 0.66 | ||
| T | 0.33 | 0.34 | 1.05 (0.66–1.68) | |
| rs17128183 A/G | n = 129 | n = 177 | ||
| AA | 54 (41.86) | 70 (39.55) | 1 | |
| AG | 59 (45.74) | 86 (48.59) | 0.88 | 1.04 (0.74–1.46) |
| GG | 16 (12.40) | 21 (11.86) | 1.08 (0.55–2.14) | |
| Alleles | ||||
| A | 0.65 | 0.64 | ||
| G | 0.35 | 0.36 | 1.04 (0.65–1.67) | |
OR, crude odds ratio; CI, confidence interval; P, Pearson Chi‐square test, P value was corrected for multiple testing of two genetic variants, and P < 0.0125 was considered statistically significant.