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. 2016 Mar 1;1(1):4–11. doi: 10.1016/j.pbj.2016.03.004

Fig. 2.

Fig. 2.

Co-stimulatory and inhibitory signals for T-cells. PD-L1 mediated inhibition of T-cells occurs via ligation to PD-1 and B7-1 on T-cells (full arrows) and through reverse signaling inhibition via ligation to B7-1 on APCs (full arrow). Also depicted are co-stimulatory and inhibitory signals mediated by CD28 and CTLA-4 on T-cells, respectively, through ligation to both B7-1 and B7-2 on APCs (dashed arrows). Adapted from: Keir et al.14.