Table 1.
Baseline Characteristics, Angiographic Data, and CE‐CMR Imaging Data on the Basis of Peak hsCRP Level
| Characteristic | Total (n = 112) | Peak hsCRP <2.35 mg/dl (n = 62) | Peak hsCRP ≥2.35 mg/dl (n = 50) | P‐value |
|---|---|---|---|---|
| Clinical characteristics | ||||
| Age (years) | 59.0 ± 10.4 | 59.4 ± 10.5 | 58.6 ± 10.3 | 0.697 |
| Male sex (%) | 85.7 | 80.6 | 92.0 | 0.088 |
| Hypertension (%) | 41.1 | 46.8 | 34.0 | 0.172 |
| Diabetes mellitus (%) | 17.9 | 16.1 | 20.0 | 0.595 |
| Dyslipidemia (%) | 11.6 | 12.9 | 10.0 | 0.633 |
| Smoking (%) | 72.3 | 67.7 | 78.0 | 0.228 |
| Prior PCI (%) | 5.4 | 4.8 | 6.0 | 0.786 |
| Killip class ≥2 (%) | 51.8 | 45.2 | 60.0 | 0.118 |
| Anterior infarction (%) | 42.9 | 40.3 | 46.0 | 0.546 |
| SBP at admission (mmHg) | 126.1 ± 24.3 | 127.6 ± 23.2 | 124.2 ± 25.7 | 0.455 |
| Initial heart rate(beat/min) | 73.5 ± 17.1 | 70.6 ± 15.6 | 77.2 ± 16.2 | 0.042 |
| Door to balloon time (min) | 79.5 ± 21.3 | 82.1 ± 24.5 | 76.1 ± 16.2 | 0.150 |
| Symptom to balloon time (min) | 264.9 ± 166.7 | 261.5 ± 162.3 | 269.1 ± 173.7 | 0.811 |
| Peak CK‐MB (ng/dl) | 222.1 ± 123.5 | 190.5 ± 115.7 | 261.3 ± 122.6 | 0.002 |
| Peak hs‐cTnT (ng/ml) | 6.39 ± 3.78 | 5.08 ± 3.41 | 8.02 ± 3.60 | <0.001 |
| Creatinine (mg/dl) | 1.00 ± 0.19 | 1.00 ± 0.18 | 1.00 ± 0.20 | 0.907 |
| MPV (fl) | 7.58 ± 1.16 | 7.42 ± 1.00 | 7.78 ± 1.32 | 0.102 |
| Baseline hsCRP (mg/dl) | 1.60 ± 2.25 | 0.48 ± 0.51 | 3.00 ± 2.76 | <0.001 |
| Peak hsCRP (mg/dl) | 3.32 ± 4.43 | 0.54 ± 0.52 | 6.78 ± 4.69 | <0.001 |
| Angiographic data | ||||
| Culprit artery | ||||
| LAD (%) | 42.9 | 40.3 | 46.0 | 0.546 |
| LCx (%) | 14.3 | 14.5 | 14.0 | 0.938 |
| RCA (%) | 42.9 | 45.2 | 40.0 | 0.583 |
| Multivessel disease (%) | 56.3 | 59.7 | 52.0 | 0.416 |
| Baseline TIMI flow grade 0–1 (%) | 79.5 | 69.4 | 92.0 | 0.003 |
| Final TIMI flow grade 3 (%) | 92.0 | 96.8 | 86.0 | 0.037 |
| Angiographic no‐reflow (%) | 2.7 | 0.0 | 6.0 | 0.051 |
| Thrombus aspiration (%) | 23.2 | 21.0 | 26.0 | 0.531 |
| Bare‐metal stents (%) | 24.1 | 21.0 | 28.0 | 0.387 |
| Stent diameter at culprit artery, mm | 3.13 ± 0.59 | 3.11 ± 0.57 | 3.15 ± 0.63 | 0.781 |
| Stent length at culprit artery, mm | 31.5 ± 18.0 | 30.6 ± 18.8 | 32.5 ± 17.2 | 0.599 |
| Glycoprotein IIb/IIIa inhibitor (%) | 57.1 | 50.0 | 66.0 | 0.089 |
| CE‐CMR imaging data | ||||
| LVEDV (ml) | 140.1 ± 32.9 | 132.8 ± 31.1 | 149.1 ± 33.1 | 0.009 |
| LVESV (ml) | 70.4 ± 28.8 | 63.0 ± 24.9 | 79.7 ± 30.9 | 0.002 |
| LV mass index (g/m2) | 89.1 ± 16.2 | 85.9 ± 14.0 | 93.5 ± 17.8 | 0.012 |
| LV EF (%) | 49.8 ± 9.8 | 52.9 ± 9.5 | 46.0 ± 8.9 | <0.001 |
| Infarct size, % of LV | 6.88 ± 5.5 | 5.30 ± 4.5 | 8.83 ± 5.9 | 0.001 |
| AAR, % of LV | 17.4 ± 11.1 | 16.2 ± 11.3 | 18.9 ± 10.9 | 0.201 |
| Myocardial salvage index (%) | 0.58 ± 0.26 | 0.63 ± 0.27 | 0.53 ± 0.24 | 0.048 |
| Hemorrhagic infarction (%) | 0.57 ± 1.27 | 0.44 ± 0.93 | 0.74 ± 1.59 | 0.220 |
| MVO area, % of LV | 0.24 ± 0.55 | 0.16 ± 0.45 | 0.34 ± 0.64 | 0.096 |
| Number of segments with >75% of infarct transmurality | 1.45 ± 1.73 | 0.94 ± 1.41 | 2.10 ± 1.88 | <0.001 |
| Maximal infarct transmurality (%) | 66.0 ± 29.0 | 55.8 ± 27.9 | 78.6 ± 25.3 | <0.001 |
| Frequency of transmural extent of infarction (%) | 46.4 | 27.4 | 70.0 | <0.001 |
a“Smoking” means active smokers as well as ex‐smokers who stopped smoking less than 1 year before enrollment.
hsCRP, high‐sensitivity CRP; PCI, percutaneous coronary intervention; SBP, systolic blood pressure; CK, creatine kinase; hs‐cTnT, high‐sensitivity cardiac troponin T; MPV, mean platelet volume; LAD, left anterior descending coronary artery; LCX, left circumflex coronary artery; RCA, right coronary artery; TIMI, thrombolysis in myocardial infarction; CE‐CMR, contrast‐enhanced cardiac magnetic resonance; LV, left ventricle; LVEDV, left ventricular end‐diastolic volume; LVESV, left ventricular end‐systolic volume; MVO, microvascular obstruction.