Table 1.
Clinical and Biochemical Demographic Data of the Studied Groups
| Items | Group | |||
|---|---|---|---|---|
| Controls (n = 50) | Samples with α‐thalassemia | |||
| Three functional α‐genes (n = 32) | Two functional α‐genes (n = 80) | One functional α‐genes (HbH disease) (n = 27) | ||
| Genotype (n) |
αα/αα (n = 50) |
‐α3.7/αα (n = 26) ‐α4.2/αα (n = 6) |
‐‐SEA/αα (n = 80) |
‐‐SEA/‐α3.7
(n = 17) ‐‐SEA/‐α4.2 (n = 10) |
| Sex | ||||
| Male (n) | n = 15 | n = 10 | n = 21 | n = 7 |
| Female (n) | n = 35 | n = 22 | n = 59 | n = 20 |
| Age (year) | 30.3 ± 7.1 | 32.7 ± 9.0 | 29.6 ± 5.4 | 29.1 ± 11.1 |
| HB (g/l) | 140.4 ± 16.1 | 126.9 ± 18.5a | 117.8 ± 13.8a | 95.0 ± 13.0a |
| MCV (fL) | 90.0 ± 3.1 | 82.6 ± 4.1a | 71.2 ± 4.3a | 65 ± 4.8a |
| MCH (Pg) | 30.2 ± 1.2 | 27.1 ± 1.5a | 21.5 ± 1.2a | 18.6 ± 0.9a |
| HbA2 (%)b | 2.9 ± 0.3 | 2.6 ± 0.3a | 2.3 ± 0.2a | 1.1 ± 0.3a |
| FG (mmol/l) | 5.03 ± 0.30 | 5.06 ± 0.37 | 4.95 ± 0.29 | 5.16 ± 0.37 |
| Fruc (μmol/l) | 209.6 ± 16.7 | 201.8 ± 19.2 | 204.2 ± 18.2 | 212.9 ± 14.8 |
| HbA1c (%) | ||||
| Ultra² | 4.90 ± 0.48 | 4.81 ± 0.38 | 4.78 ± 0.41 | 3.84 ± 0.58a |
| VT 2.0 | – | – | – | 3.73 ± 0.47 |
| CFP | ||||
| HbA1c | 5.01 ± 0.46 | 4.93 ± 0.36 | 4.97 ± 0.33 |
4.07 ± 0.33 (n = 18) a |
| HbA2 c | 2.7 ± 0.3 | 2.4 ± 0.3a | 2.1 ± 0.2a | 1.0 ± 0.3a |
| oFS | – | – | – | 3.91 ± 0.37 |
–, HbA1c was not analyzed.
a
There was statistically significant bias between the control and test groups (P < 0.05).
b
HbA2 values from the C2FP hemoglobin system.
c
HbA2 values from the C2FP HbA1c system.