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. 2019 Oct 23;8(10):1303–1308. doi: 10.1002/open.201900222

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© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Phenotypic spheroid invasion assay (SIA). (a) Examples of microscopy images showing the effects of compounds 1 and 2, the untreated control, and AMD3100. (b) Activity of computational designs 1 and 2 in the SIA. CXCR4 antagonist AMD3100 for comparison. Cell migration was induced by compounds 1, 2, and the known CXCR4 antagonist AMD3100. This effect was abrogated by siRNA mediated CXCR4 silencing. Non‐targeting (nt) siRNA had no effect. Results are given as mean±S.E.M.; N=3 independent repetitions with n=3 technical replicates each; *p<0.05, **p<0.01, ***p<0.001 (one‐way ANOVA with Kruskal‐Wallis test).