Figure 7.

Differential NPY/Y2 Activation Dynamics in Treated Animals Might Prolong Inter-SRS Intervals and Ameliorate Disease State

Seizures lead to postictal refractoriness (less excitability) that might accumulate over time, leading to termination of the SRS clusters. In control animals, the contribution from each SRS to postictal refractoriness is modest, leading to short inter-SRS intervals, both within and between clusters (black trace). We hypothesize that, in NPY/Y2-treated animals, the releasable pool of NPY is enlarged and available Y2 receptors are more abundant. Each SRS would then lead to a longer refractory period due to decreased excitability. This is reflected in longer inter-SRS intervals within and between clusters (magenta trace).