Figure 5.

Protection of injured axons from degeneration in raw mutants requires the transcription factors Fos and Jun and the JNK MAP kinase. A, Single motoneuron axons are labeled by membrane bound mCD8::GFP driven by the m12-Gal4 driver. As shown in Figure 1, axonal degeneration is strongly delayed in raw^dcp-1 animals. Expression of dominant negative forms of Jun and Fos (Jun^DN and Fos^DN) partially rescue the protective effect in raw^dcp-1 animals. B, Quantification of axon degeneration scores in indicated genotypes. Scale bar, 20 μm. Error bars indicate SEM. ****p < 0.0001, *0.01 < p < 0.05 (p = 0.0445). ns (p > 0.05), one-way ANOVA test; n ≥ 25 axons from 5 animals per condition.