Figure 10.

Evaluation of the Nrf2 pathway in PBMC of NVHL rats (n = 5/group). A, GSK-3β ratio levels increased in NVHL animals and RISP treatment reduced them in these rats (^αlesion effect: p = 0.028; *p < 0.05 vs all the other groups). B, Keap1 protein levels remained unchanged among groups. C, The RISP effect of increasing Nrf2 protein levels was close to the significance threshold (^βRISP effect: p = 0.064). Statistical analyses were conducted using a two-way ANOVA, Newman Keuls post hoc test.