Skip to main content
. 2019 Oct 23;39(43):8584–8599. doi: 10.1523/JNEUROSCI.1249-19.2019

Figure 6.

Figure 6.

NVHL disrupts the BDNF/TrkB pathway in the PFC. Representative Western blot images of each protein and group (n = 5/group). A, BDNF did not change among groups. B, The NVHL effect of reducing TrkB-FL levels was close to significance threshold, however, RISP treatment increased them (αlesion effect: p = 0.062; βRISP effect: p = 0.005). C, TrkB-T1 remained unchanged among groups. D, TrkB-FL/T1 ratio increased because of RISP (βRISP effect: p = 0.001). E, NVHL reduced PI3K levels and RISP increased them (αlesion effect: p = 0.001; βRISP effect: p = 0.001). F, Akt increased in the NVHL rats after RISP treatment (*p < 0.05 vs NVHL-vehicle). G, RISP increased ERK-ratio levels and recovered the decrease in the NVHL animals (βRISP effect: p = 0.009; #p < 0.05 vs both sham groups, p < 0.01 vs NVHL-RISP). Statistical analyses were conducted using a two-way ANOVA, Newman Keuls post hoc test.