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. 2019 Oct 23;39(43):8584–8599. doi: 10.1523/JNEUROSCI.1249-19.2019

Figure 8.

Figure 8.

NVHL impairs the Nrf2 pathway in the PFC of NVHL rats (n = 5/group). A, NVHL increased GSK-3β levels (αlesion effect: p = 0.04). B, Also NVHL increased Keap1 protein levels, and because the interaction between factors was very close to significance threshold, a post hoc test was made and revealed that RISP decreased Keap1 levels in NVHL animals (αlesion effect: p = 0.005; #p < 0.05 vs RISP-treated groups and p < 0.01 vs sham-vehicle). C, NVHL reduced Nrf2 levels and RISP increased them (αlesion effect: p = 0.003; βRISP effect: p = 0.04). Statistical analyses were conducted using a two-way ANOVA, Newman Keuls post hoc test.