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. 2019 Oct 23;39(43):8584–8599. doi: 10.1523/JNEUROSCI.1249-19.2019

Figure 9.

Figure 9.

Oxidative/nitrosative stress was observed in the periphery of NVHL rats (n = 5/group). A, IκBα increased after RISP treatment (βRISP effect: p = 0.008). B, NF-κB levels remained unchanged. C, COX-2 increased as a consequence of NVHL and RISP treatment (βRISP effect: p = 0.008). D, PPAR-γ protein levels remained unchanged. E, NO2− concentration increased because of NVHL (αlesion effect: p = 0.045). F, iNOS protein levels, as well as (G) MDA concentration remained unchanged among experimental groups. H, RISP reduced the 4-HNE protein levels in NVHL animals (*p < 0.05 vs NVHL-vehicle). Statistical analyses were conducted using a two-way ANOVA, Newman Keuls post hoc test.